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Dr. Andrew Rynne
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Dr. Andrew Rynne

Family Physician

Exp 50 years

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Asked To Take AKT4, TBPCR, AFB Tests Show Negative. Why Have The Medicines Been Prescribed?

hi, I am animesh, from howrah,India. my wife was suffering from cist on right overy. size 3.6 cm. dr. operted it by laproscopy . But after 4th week infection took place.DRs used different types of antibiotics .no result. PUS was passing continuously.dr usde tab loxof and azimox and then rcinex 450. sometimes it shown some improvement but position remains same. by this way 5months already passed. finally Dr used AKT4 but so far pathologcal report of PUS culture,AFB test, TBPCR report all are shown negetive. that is my point of concern? now DR advised to take AKT4 for 3months along with bactrim d.s. and bicosule. she has elergic problems which try to controll through diet. Now, my questions are 1.How shoud I confirm about TB 2.will she continue AKT4 {already taken for13 days} 3.is there any alternate ? Test to confirm TB disease . 4.what is it side effect?
posted on Sat, 25 Aug 2012
Twitter Tue, 28 Aug 2012 Answered on
Twitter Tue, 28 Aug 2012 Last reviewed on
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Pulmonologist,  's  Response
Hi Mr. Animesh Patra,
thanks for writing in.
many a times organism of TB cannot be found though we have to use anti-tubercular drugs depending upon the clinical background.
post-operatively NTM ( non-tubercular mycobacterial) infection is increasing now. I have seen many such cases in a renouned hospital in kolkata. I dont know what type of culture of the pass had been done. It should be mycobacterial culture BACTEC of the pass that will grow mycobacteria though may take time upto 6 weeks. Culture is the only to confirm your TB diagnosis.
Yes i think she should continue AKT4 as she already started. It means nothing to stop it in the mid-way.
alternate regime is already been tried by your physician.
ATD has many side effects like nausea, vomiting, liver derangement, visual problems, hyperuricemia, peripheral neuropathy. but in the dose of AKT4 nothing serious usually happens. but if any complication arises please do consult your doctor immediately and better to have a monthly LFT measurement.
thank you
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Asked To Take AKT4, TBPCR, AFB Tests Show Negative. Why Have The Medicines Been Prescribed?

Hi Mr. Animesh Patra, thanks for writing in. many a times organism of TB cannot be found though we have to use anti-tubercular drugs depending upon the clinical background. post-operatively NTM ( non-tubercular mycobacterial) infection is increasing now. I have seen many such cases in a renouned hospital in kolkata. I dont know what type of culture of the pass had been done. It should be mycobacterial culture BACTEC of the pass that will grow mycobacteria though may take time upto 6 weeks. Culture is the only to confirm your TB diagnosis. Yes i think she should continue AKT4 as she already started. It means nothing to stop it in the mid-way. alternate regime is already been tried by your physician. ATD has many side effects like nausea, vomiting, liver derangement, visual problems, hyperuricemia, peripheral neuropathy. but in the dose of AKT4 nothing serious usually happens. but if any complication arises please do consult your doctor immediately and better to have a monthly LFT measurement. thank you