Hi, Thanks for your question. I do understand your pain and discomfort. As per your history is concerned the drug [Arimidex] contains [anastrozole] which is used to lower estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body.As far as side effect is concerned it is as below:- a)Cardiovascular-hypertension,edema, b)Musculoskeletal-Arthritis/arthralgia/arthrosis/joint disorder/joint pain/joint stiffness ,back pain ,bone pain,osteoporosis,fracture, Myalgia,anorexia c)Gastrointestinal-Nausea,vomiting,Abdominal pain, diarrhea, constipation, dyspepsia, gastrointestinal disorder, dry mouth d)Psychiatric-Mood disturbances , depression, insomnia e)Nervous system-Headache ,depression,insomnia , Dizziness, anxiety, paresthesia, hypertonia, cerebrovascular event,somnolence, confusion, nervousness, carpal tunnel syndrome, sensory disturbances etc f)Dermatologic-Rash,Sweating, hair thinning, pruritus,Skin reactions , erythema multiforme, cutaneous vasculitis, Stevens-Johnson syndrome g)Respiratory-Dyspnea ,cough,pharyngitis,Sinusitis, bronchitis, rhinitis etc h)Genitourinary-Urinary tract infection, breast pain, vulvovaginitis, vaginal hemorrhage, vaginitis, vaginal discharge, vaginal bleeding, vaginal dryness, pelvic pain, leukorrhea etc i)Hematologic-Anemia, leukopenia j)Hepatic-Increased gamma GT, increased SGOT, increased SGPT, increased alkaline phosphatase,increased bilirubin,liver inflammation, liver pain, liver swelling k)Metabolic-Weight gain, hypercholesterolemia, weight loss, anorexia,Hypercalcemia. l)Ocular-Cataracts m)Hypersensitivity-Allergic reactions ,Urticaria,anaphylactoid reaction,Angioedema n)Oncology-Neoplasm, tumor flare,Endometrial cancer which is very rare indeed(0.1-1% only) So if you have at menopause better remove both uterus and ovaries. I hope I was able to address your query. If you have any further questions, please do not hesitate to write to me. Wishing you all the best. Thanks Dr U N Sahoo