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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Coumadin Be Substituted With Xarelto For INR Rate Maintenance?

I am 88 years old man I had surgical operation from my heard in 2007 /4/april ( by pass operation ) from that time I m taking COUMADİN 5 Mg (varfarin sodyum ) for INR rate every mounth Im giving blood. can I take new medıcıne XRELTO instead coumadin ? Thank you very much for your help.
Wed, 26 Jun 2019
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Internal Medicine Specialist 's  Response
Hi,

Rivaroxaban (Xarelto ) can be taken in place of warfarin provided your creatinine clearance (Cr Cl) or e-GFR is suitable. For example a standard dose of Rivaroxaban-CrCl >50 ml/min -20 mg once daily with evening meal; CrCl 15-50 ml/min -15 mg once daily with the evening meal. Also, you should not take the following drugs like ketoconazole, erythromycin or clarithromycin, amiodarone, rifampicin etc. due to drug interaction. Consult your doctor.

Hope I have answered your query. Let me know if I can assist you further.

Regards,
Dr. Tushar Kanti Biswas, Internal Medicine Specialist
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Can Coumadin Be Substituted With Xarelto For INR Rate Maintenance?

Hi, Rivaroxaban (Xarelto ) can be taken in place of warfarin provided your creatinine clearance (Cr Cl) or e-GFR is suitable. For example a standard dose of Rivaroxaban-CrCl 50 ml/min -20 mg once daily with evening meal; CrCl 15-50 ml/min -15 mg once daily with the evening meal. Also, you should not take the following drugs like ketoconazole, erythromycin or clarithromycin, amiodarone, rifampicin etc. due to drug interaction. Consult your doctor. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Tushar Kanti Biswas, Internal Medicine Specialist