Can I use aspirin as an anticoagulant treatment for Protein S Deficiency? I am a police officer and the city I work for is going to make me retire because I take Warfarin. I had a DVT/PE and have been taking Warfarin ever since. Also, I want to be retested because I think my test was a false positive for the protein s deficiency. When I was released from the hospital I took shots for about 5 days then started taking the Warfarin. About 5 weeks later I had blood work done and was later told I had I the protein S deficiency. I have recently learned that my results could be a false positive because because I was on the Warfarin. I recently saw a hematologist who said he would not take the chance having me retested because I could get another clot in the 4-6 weeks needed to be off the medicine in order to get properly retested. Family History: I am 46 and my mother passed away due to DVT/PE. My sister had DVT. All 3 of my sisters have tested negative for the protein S deficiency. I am really want to be retested and stop taking Warfarin. I was hoping and Aspirin could be an alternative. I am healthy, active, 5 11 205 pounds. Thank you, John