Hi, MX 5 lotion (Minoxidil) is a local vasodilator, means it will increase blood flow to the area it is applied, but it is known to get systemically absorbed, so you have to be cautious while applying it, like do not rub it much on the scalp, wash your hands after the application and it will work like wonder for you.Few other side effects are slight burning and redness at the application area but they are minor once. and kz lotion (ketoconazole) is an antifungal agent. Don t worry about it, it doesn t have any serious side effects. You can use both of them very effectively. I hope this was helpful to you.