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Dr. Andrew Rynne
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Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can TBG Deficiency Cause Sluggish Thyroid?

I have inherited TBG deficiency. I have been diagnosed with a sluggish thyroid by my PCP and to start Levothyroxine 25 mcg. When you have TBG deficiency it changes how the results are interpreted. Would my T3 and FT4 be high or low in each? I will be talking to my primary tomorrow and I just want to make sure that my numbers are truly showing Hypothyroidism and not due to the TBG deficiency. Thank You,
posted on Sat, 1 Aug 2015
Twitter Mon, 24 Jun 2019 Answered on
Twitter Wed, 26 Jun 2019 Last reviewed on
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Endocrinologist,  's  Response
Hello,

If Hashimoto thyroiditis is confirmed than hypothyroidism is due to it, if no cause is found, then it may be due to TBG deficiency.

Hope I have answered your query. Let me know if I can assist you further.

Take care

Regards,
Dr Mirjeta Guni, Endocrinologist
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Can TBG Deficiency Cause Sluggish Thyroid?

Hello, If Hashimoto thyroiditis is confirmed than hypothyroidism is due to it, if no cause is found, then it may be due to TBG deficiency. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr Mirjeta Guni, Endocrinologist