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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Trazodone And Cymbalta Be Taken Together?

My husband had a brain tumor removed 3 weeks ago. the doctor put him on trazodone 50mg to help him sleep at night.He also put him on Cymbalta 60 mg for depression.He stays so weak all the time and sleeps a lot.Could either of these medicine be the cause ,and is it ok to take these two medicines together?
Thu, 17 Nov 2016
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General & Family Physician,  's  Response
Hi & Welcome.

Yes, if taken together it may cause harmful effects.

Taking Cymbalta while on Trazodone can increase the risk of a rare but serious condition called the serotonin syndrome characterized by symptoms such as confusion, hallucination, seizure, extremely high BP, increased heart rate, fever, excessive sweating, blurred vision, muscle stiffness, tremor, incoordination, nausea, vomiting, and diarrhea.

Sometimes it may result in coma and even death.

So, in view of the above it is not safe to take these two medications together. Consult his treating doctor for an alternate effective but a safer medication to treat his prolonged sleep.

Hope this will help him/
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Can Trazodone And Cymbalta Be Taken Together?

Hi & Welcome. Yes, if taken together it may cause harmful effects. Taking Cymbalta while on Trazodone can increase the risk of a rare but serious condition called the serotonin syndrome characterized by symptoms such as confusion, hallucination, seizure, extremely high BP, increased heart rate, fever, excessive sweating, blurred vision, muscle stiffness, tremor, incoordination, nausea, vomiting, and diarrhea. Sometimes it may result in coma and even death. So, in view of the above it is not safe to take these two medications together. Consult his treating doctor for an alternate effective but a safer medication to treat his prolonged sleep. Hope this will help him/