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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Wellbutrin Be Taken While On Oxycodone?

My wife has been on paxil for years. She is having a lobectomy for adenocarcinoma next week. She still smokes. Our new internal medicine dr gave her wellbutrin xl to stop smoking. After surgery she will probably be on oxycodon. Both these drugs are listed for interactions. Is it safe to start the wellbutrin now? email address is YYYY@YYYY . Thank you, Darrell Umbarger
Sat, 12 May 2018
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General & Family Physician 's  Response
Hello and Welcome to ‘Ask A Doctor’ service.
I have reviewed your query and here is my advice.

It's not safe to take Wellbutrin while on Oxycodone. Wellbutrin may cause seizures, and combine it with other medications that can also cause seizures such as Oxycodone may increase that risk. Your wife may be more susceptible if she is elderly, have a history of seizures, or have a condition affecting the central nervous system such as a brain tumor or head trauma.

In a similar way combining Wellbutrin with Paxil may also increase the risk of seizures, which may occur rarely with either medication. Consult her doctor to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications.

Hope I have answered your query. Let me know if I can assist you further.

Regards,
Dr. Mohammed Taher Ali
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Can Wellbutrin Be Taken While On Oxycodone?

Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. It s not safe to take Wellbutrin while on Oxycodone. Wellbutrin may cause seizures, and combine it with other medications that can also cause seizures such as Oxycodone may increase that risk. Your wife may be more susceptible if she is elderly, have a history of seizures, or have a condition affecting the central nervous system such as a brain tumor or head trauma. In a similar way combining Wellbutrin with Paxil may also increase the risk of seizures, which may occur rarely with either medication. Consult her doctor to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Mohammed Taher Ali