Can Autoimmune Estrogen Dermatitis Be The Cause Of Miscarriages?

My wife and i have been going through IVF. She has had 4 miscarriages so far without a solid reason or explaination why. She has broken out in a small rash the past attempts but has broken out in as much larger rash this attempt. We are thinking that it is autoimmune estrogen dermatitis. Can this cause miscarriages and could this be an explaination for the past failed attempts? If so, what can be done so right this. Thank you for any help you can give