Hi, Thanks for writing in. Ependymomas are tumors affecting the brain and spinal cord where there is ependymal lining. In the brain there is ependymal lining in the ventricles and in the spinal cord it is present in the spinal canal. Since there is fluid along the ependymal lining, it is easy for these tumors to seed elsewhere and regrow, even after surgery and radiation treatment. As a result the patient can have recurrence of the tumor at the same site or another place. The main treatment is surgery to remove as much as possible of the tumor and then follow up closely to include chemotherapy. These treatments can slow down the growth of the tumor and help to reduce symptoms. Chemotherapy involves treating with medicines like the following Carboplatin Carmustine Cisplatin Cyclophosphamide Etoposide Lomustine Methotrexate Vincristine Usually you would have a number of these drugs together as combination chemotherapy. Please do not worry.