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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Could My Missed Period On Day 40 With Sore Breasts Be Pregnancy, Or Is It A Clomiphene Side Effect?

I have been trying to conceive for a year , have been prescribed clomephene for two cycles and folic acid for three months , now i havent seen my period its day 40 of cycle could it be pregnancy or clomiphene can later cycle days , my breast are sore from two weeks ago
posted on Thu, 21 Aug 2025
Twitter Tue, 16 Sep 2025 Answered on
Twitter Tue, 30 Sep 2025 Last reviewed on
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General & Family Physician,  's  Response
Hello,

You have been taking Clomiphene, and it can delay your cycle and cause sore breasts. However, since you are trying to conceive and are taking clomiphene, this could be pregnancy, since you’re late. Sore breasts starting 2 weeks ago could mean a rise in progesterone after ovulation, or it could be an early pregnancy sign. Day 40 without a period is considered late in most cycles, so you are advised to take a home urine pregnancy test, preferably first morning urine for best accuracy.

If negative but still no period, repeat in 3–4 days. If it is still negative and there is no period by day 45–50, then you are advised to get clinically examined by your gynecologist. Your gynecologist will recommend you get a blood test (beta-hCG) done. You should also do USG to confirm pregnancy.

Take care. Hope I have answered your question. Let me know if I can assist you further.

Regards,
Dr. Nupur K., General & Family Physician
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Could My Missed Period On Day 40 With Sore Breasts Be Pregnancy, Or Is It A Clomiphene Side Effect?

Hello, You have been taking Clomiphene, and it can delay your cycle and cause sore breasts. However, since you are trying to conceive and are taking clomiphene, this could be pregnancy, since you’re late. Sore breasts starting 2 weeks ago could mean a rise in progesterone after ovulation, or it could be an early pregnancy sign. Day 40 without a period is considered late in most cycles, so you are advised to take a home urine pregnancy test, preferably first morning urine for best accuracy. If negative but still no period, repeat in 3–4 days. If it is still negative and there is no period by day 45–50, then you are advised to get clinically examined by your gynecologist. Your gynecologist will recommend you get a blood test (beta-hCG) done. You should also do USG to confirm pregnancy. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Nupur K., General & Family Physician