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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Diagnosed With PTB3. Doctor Changed The Medicine Since The Previous One Caused Fever. SGOT, SGPT High. Liver Damage?

Hi, my husband has diagnosed with PTB III and taking medicine but after a week he stopped taking medicine because it causes him fever. The doctor changed the medicine into another brand but same generic name which is rifambicin isoniazid, i can't remember the brand name but there is a number 4. The doctor made some laboratory test and in the result of his blood chemistry vitros 250 result the sgot and sgpt are high?may i know if my husband has a liver failure or problem in his liver? thank you.
Thu, 21 Nov 2013
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Pediatrician,  's  Response
Hello,

Your husband has been diagnosed with pulmonary tuberculosis and started on treatment for the same. You mentioned that he is on a brand with a number 4. So i presume he is on 4 drugs which is standard treatment for initial phase of TB. Besides isoniazid and rifampicin, i think he must also be receiving pyrazinamide and ethambutol. Now anti tubercular drugs are known to cause hepatitis. The elevated SGOT and SGPT levels of your husband are most likely due to drug induced hepatitis. In this situation your husband will be continued on ethambutol and the other 3 drugs will be stopped. Your doctor may add other anti tubercular drugs. His SGPT, SGOT and serum bilirubin should be repeated weekly and gradually these drugs can be restarted after his SGPT and SGOT levels come down. But please do not discontinue the medicines altogether without consulting a doctor as this can lead to drug resistance in patients of TB.
I advice you to consult a doctor and have his treatment modified.

Hope that helps.
Wishing you good luck.

Regards,
Dr. Preeti
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Diagnosed With PTB3. Doctor Changed The Medicine Since The Previous One Caused Fever. SGOT, SGPT High. Liver Damage?

Hello, Your husband has been diagnosed with pulmonary tuberculosis and started on treatment for the same. You mentioned that he is on a brand with a number 4. So i presume he is on 4 drugs which is standard treatment for initial phase of TB. Besides isoniazid and rifampicin, i think he must also be receiving pyrazinamide and ethambutol. Now anti tubercular drugs are known to cause hepatitis. The elevated SGOT and SGPT levels of your husband are most likely due to drug induced hepatitis. In this situation your husband will be continued on ethambutol and the other 3 drugs will be stopped. Your doctor may add other anti tubercular drugs. His SGPT, SGOT and serum bilirubin should be repeated weekly and gradually these drugs can be restarted after his SGPT and SGOT levels come down. But please do not discontinue the medicines altogether without consulting a doctor as this can lead to drug resistance in patients of TB. I advice you to consult a doctor and have his treatment modified. Hope that helps. Wishing you good luck. Regards, Dr. Preeti