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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Does Allopurinol Cause Severe Peripheral Neuropathy?

I have been taking Allopurinol for about 35 years. Initially 300 mg for years and for the last 10 years 200mg daily. I am not diabetic and I am under medication for high blood pressure.I have severe PN and my Neurologist feels that myPN was caused by long term Allopurinol. I ve stopped taking it for about a month. What do you think?
Mon, 2 Jul 2018
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  Anonymous's Response
's  Response
Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice.

Neuropathy is a very very rare side effect of Allopurinol, which usually makes the pain and stiffness worse during gout attack. In your case, if the neuropathy has been subsided a month later from last pill, then Allopurinol should be blame. If not, obviously further investigations are needed.

Hope I have answered your query. Let me know if I can assist you further.

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Does Allopurinol Cause Severe Peripheral Neuropathy?

Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. Neuropathy is a very very rare side effect of Allopurinol, which usually makes the pain and stiffness worse during gout attack. In your case, if the neuropathy has been subsided a month later from last pill, then Allopurinol should be blame. If not, obviously further investigations are needed. Hope I have answered your query. Let me know if I can assist you further.