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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Does Cyclosporine Cause Damage To Kidneys In Long Run?

I am seetaramarao of age 37. i am using the cyclosporine 50mg since 12yrs. I heard that long usage of this medicine will cause damage to kidney and gradual increase in creatinine levels. recently ihave done the biopsy to my transaplanted kidney and doesnot shows any cyclosporine toxins. please suggest me, do i switch to new drug or can i continue my medication as below.

cyclosporine 50mg (morning) 50mg (evening) Aten 50mg 1, Azoran 25mg day by day, Prednisomone 5 mg -1, Amlosafe 5MG -1.

Transplanted date 1-4-1998. donor -own bother

                                                                 
posted on Thu, 13 Mar 2014
Twitter Tue, 1 Aug 2017 Answered on
Twitter Tue, 1 Aug 2017 Last reviewed on
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Nephrologist,  's  Response
Dear Patient,

the answer is: it depends. In fact, the dose you are taking is very low, thus you are on a perfect balance without high levels of immune suppression. Calcineurin inhibitors may be nephrotoxic if blood levels are constantly high (>150 ng/ml) since they cause tubular and endothelial toxicity, leading to tubulo-interstitial scarring, arterial ialinosis and glomerular ischemia. At low doses, calcineurin inhibitors are even protective for the podocytes. Thus, I recommend you to continue on cyclosporine, this is an awesome drug.
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Does Cyclosporine Cause Damage To Kidneys In Long Run?

Dear Patient, the answer is: it depends. In fact, the dose you are taking is very low, thus you are on a perfect balance without high levels of immune suppression. Calcineurin inhibitors may be nephrotoxic if blood levels are constantly high ( 150 ng/ml) since they cause tubular and endothelial toxicity, leading to tubulo-interstitial scarring, arterial ialinosis and glomerular ischemia. At low doses, calcineurin inhibitors are even protective for the podocytes. Thus, I recommend you to continue on cyclosporine, this is an awesome drug.