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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Does Metformin Cause Vaginal Itching And Continuous Bleeding?

Hi doctor.i am 29 years old and I have been declared pcos since last two months.my doctor prescribed me metformin and progluton but the problem is when I use medicine a vaginal itching and vaginal discharge continue.i want to ask is it normal with this kind of medicine or I have a vaginal infection?if it is a infection then what are the chances of getting pregnant?what should I do?
Mon, 24 Feb 2014
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General & Family Physician 's  Response
Hi,
PCOD is a condition where ovulation does not occur & so chances of conception are rare,till ovulation improves.It is better to control infection while you get treatment for the PCOD.
Metformin is used to control the pcod. Progyluton is a hormone preparation in very low dose-given to avoid maturation of ovum & there by give rest to the stressed ovary.
The itching you have with white discharge is mostly due to trichomonal infection-being exagareted with hormonal pills (Progyluton) when you start them.
I would advice you to consult your gynecologist for examination & treatment of the infection. usually in such cases,patient is advised to stop the hormone(Progyluton) for a couple of months & a course of metranidazole (oral/local) is given to both partners.
Thanks.
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OBGYN Dr. Cori Baill's  Response
PCOS, a blunted cycling mechanism resulting in missed periods, is also tied to glucose intolerance, even if you haven't been diagnosed as an adult onset diabetic. Metformin lowers blood sugar by decreasing insulin resistance and can help reestablish normal cycles even in nondiabetic PCOS patients. Elevated sugar can cause vaginal itching and burning if yeast is growing, and yeast likes a high sugar environment. Metformin should decrease sugar, making yeast less common.
However, the problem may be the Progyluton, which are estrogen and progestin hormones that are used to treat menopause symptoms. The medication is spelled a little different, but its the closest to the one in your question, so double check the spelling to be sure if I have it right. At 29, this medicine is usually prescribed for women with no hormone production, ovarian failure, not just a resistance to cycling. It isn't birth control, and if metformin helpds to reestablish ovulation, it won't prevent preganacy. Progyluton should not be taken in pregnancy so it is important to return or contact the prescribing doctor and find out why you are taking this medicine. If a woman hasn't been making hormones for a while, the pH and texture changes in the vagina. The vagina and vulva becomes more alkaline, and thin. It also dries out a great deal, and the driness inhibits the growth of bacteria nad fungus such as yeast. Eventually once a normal hormonal environment is reestablished and the vagina is acidic, the pH change inhibits infection, as does the thicker skin. The problem occurs during the transition from no hormonal to a hormonally replete. There are a few weeks when there is more moisture and glucose which yeast likes, but not enough thickness, and acidity to resist and inhibit yeast growth. SO yes, the meds may be causing itching, watery or white clumpy discharge without significant odor. A quick simple exam will confirm the problem, but you could also try over the counter creams to treat yeast infections, and if your symptoms improve you have your answer. The problem will resolve if you stay on the medication long enough to change the pH and thicken the skin, especially if your blood sugar is normal.
Though it isn't your question exactly, if you are interested in becoming pregnant, and I understand the meds you are taking, then its time to consider a medication change with your treating physician.

This has nothing to do with trichamonis. I disagree with the other doctor.
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Does Metformin Cause Vaginal Itching And Continuous Bleeding?

Hi, PCOD is a condition where ovulation does not occur & so chances of conception are rare,till ovulation improves.It is better to control infection while you get treatment for the PCOD. Metformin is used to control the pcod. Progyluton is a hormone preparation in very low dose-given to avoid maturation of ovum & there by give rest to the stressed ovary. The itching you have with white discharge is mostly due to trichomonal infection-being exagareted with hormonal pills (Progyluton) when you start them. I would advice you to consult your gynecologist for examination & treatment of the infection. usually in such cases,patient is advised to stop the hormone(Progyluton) for a couple of months & a course of metranidazole (oral/local) is given to both partners. Thanks.