My doctor insists that twynsta is not the cause of depression, fuzzy thinking, insomnia, joint pain and stiffness, anxiety, chest pains that have noticeably appeared since beginning twynsta. My quality of life has changed dramatically and is affecting my performance at work. are these side effects of Twynsta or is it all in my head as my doctor would have me believe. how do a find a medication to control my bloodpressure and still retain my quality of life.