In my opinion which is supported by various clinical texts, both escitalopram (lexapro) and bupropion (buspar) should NEVER be combined together. It can have drastic life threatening consequences. Using the together can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Severe cases may result in coma and even death. I hope i have clarified your worries. wish your husband a speedy recovery Thanks