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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Had Anticoagulation Therapy. What Could Be Causing Consistently High D-dimer?

I had a P.E last year, which there was no cause found. I have had 6 months of anticoagulation therapy . I had my d-dimer retested 3 months ago and it was found to still be high (this was 3 months into anticoagulation). I have just had my d-dimer again and it is still high - around the 3000 mark. I have had a CT scan also 3 months ago to rule out any further clots which came back clear. I want to know what could be causing my consistently high d-dimer?
Tue, 9 Apr 2013
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Hello and thanks for the question.

Of course the concern is that the elevated D-dimer may reflect active blood clotting in your body.

I would suggest that in addition to the CT which was already done that your doctors check an ultrasound of your lower extremities to make sure there is no DVT.

There are other things which may elevate the D-dimer including inflammation. If you have any underlying inflammatory disorder such as rheumatoid arthritis or chronic kidney disease or lupus.

If your doctor decides to stop the warfarin you should be followed closely for recurrence of the thrombosis.

Thanks again for sending the query. Pleae let us know if you have any additional concerns.

Dr. Galamaga
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Had Anticoagulation Therapy. What Could Be Causing Consistently High D-dimer?

Hello and thanks for the question. Of course the concern is that the elevated D-dimer may reflect active blood clotting in your body. I would suggest that in addition to the CT which was already done that your doctors check an ultrasound of your lower extremities to make sure there is no DVT. There are other things which may elevate the D-dimer including inflammation. If you have any underlying inflammatory disorder such as rheumatoid arthritis or chronic kidney disease or lupus. If your doctor decides to stop the warfarin you should be followed closely for recurrence of the thrombosis. Thanks again for sending the query. Pleae let us know if you have any additional concerns. Dr. Galamaga