Hello Tracy, Usually when there is recurrent kidney infection/pyelonephritis/UTI then other underlying diseases conditions should be investigated notably kidney stones or urinary system abnormally or malformations especially in children. If an adolescent or adult, then underlying conditions like diabetes, vaginal infections etc should be checked further. Antibiotics might not get rid of the pain if there are kidney stones. It might get rid of the bacteria infection but not the pain as it will be caused by the stones. At this point it will be advisable to run an image scan (ultrasound or CT scan) to find out if there are stones. In addition to your antibiotics you should encourage your daughter to drink more fluids and also take OTC antispasmodics such as spasfon or buscopan or analgesic pain killers. You may consult a nephrologist for further assistance. Hope this helps and wish you the best