Hi, You have a rather rare condition because VWF causes bleeding because it affects your blood clot formation, but on the other hand you also have Factor V deficiency which causes blood to clot unnecessarily. Having both of these diseases together is well very very rare. Both diseases have their separate treatment. But since both treatments work against each other, its very hard to approach your case. So instead of medication I am going to tell you some changes you can make to your lifestyle that may help- Staying active and keeping within normal ranges of BMI Avoiding bruising quit smoking avoid long trips in cars and airplanes, unless you can have a break in between them use a soft toothbrush be careful with sharp objects and go in for regular check ups to your hematologist, monitoring your condition is very important as you are a very case. I hope this answered your question.