Hi! Welcome to HCM! In normal individuals, the immune system produces antibodies to foreign proteins but not to human proteins (autoantigens). In some individuals, antibodies to human antigens are produced called autoantibody.ANAs are autoantibodies. There are many subtypes of ANAs such as anti-Ro antibodies, anti-La antibodies, anti-Sm antibodies, anti-nRNP antibodies, anti-Scl-70 antibodies, anti-dsDNA antibodies, anti-histone antibodies, anti-centromere antibodies and anti-sp100 antibodies. Each of these antibody subtypes binds to different protein complexes within the nucleus The ANA test detects the autoantibodies present in an individual s blood serum. The common tests used for detecting and quantifying ANAs are indirect immunofluorescence and enzyme-linked immunosorbent assay (ELISA). In immunofluorescence, the level of autoantibodies is reported as a titre while in ELISA there is a cut off range above which test is said to be positive. A positive ANA test is seldom useful if other clinical or laboratory data supporting a diagnosis are not present. Anti-Sm antibodies test frequency means approximately 99% of individuals with anti-Sm antibodies have SLE, but only 15-30% of people with SLE have the Sm antibodies. Your Anti-nuclear ribonucleoprotein antibodies are high,they are found in 30–40% of SLE. They are often found with anti-Sm antibodies, but they may be associated with different clinical associations. In addition to SLE, these antibodies are highly associated with mixed connective tissue disease. I sincerely hope this will help you!Take care!