Recently my doctor changed my bp medication by adding another one to the mix. after a couple of months I noticed that I was losing weight, and also found that my lips were becoming dryer than usual. As time went on, upon waking my lips were crusty and I had to apply chap stick frequently during the morning to lubricate them. Then my lips got redder than normal and eventually I had a rash on them. Understanding that it was likely an allergic reaction, I started eliminating things I thought may have been the problem. Finally, I was reduced to visiting my family physician who prescribed steroids to get rid of the rash. In the meantime, I took my daughter to see the same doctor for a sinus infection. Since I was there anyway, I told my doctor that at the same time my lips were getting better, so was the edema in my legs. He stated that with the elimination of inflammation I was able to eliminate the swelling as well. I had skinny ankles again and was not sure why the steroids had caused the change. My legs and ankles had been swelling each day to about twice normal size up to that point. They called me from his office the next week after my original visit to tell me that the results of blood tests taken at the previous visit showed that my TSH was low. Low thyroid, and I was losing weight, how could that be? I was also asked if there was something that I was routinely taking that would cause the allergic reaction I had experienced. As I was telling my husband about what they asked he remembered that he read on the paperwork that comes with my new bp medication that it could cause thyroid problems. Ok, so my next step was to ask the pharmacy for a copy of that information. Indeed all that symptoms I was having were likely caused by the new medication. Not good news at all in my opinion. I quit taking it immediately, and took the paper to my doctor. Now, for the question. I also am experiencing a lump on the inside of my left shin bone. this lump is about two inches in length and one inch wide. Is there any reason to believe that this has something to do with low TSH?