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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Having Psychosis And Dementia.Was On Haldol, Now Seroquel. Is It Possible She Will Stay Psychotic?

My mother is 75 years has been in the psychiatric ward since 5/26/13 for psychosis. As per doctor early stages of dementia. She is hallucinating, delusional agitated and aggressive. She was on haldol for 2 weeks now on seroquel. Eating very little, sleeping few hours. The first few days on seroquel she started eating sleeping better, mood improve, then slowly again she started getting agitated, little sleep,little eating. Yesterday she lost it started screaming recking her room, fighting and cursing. She had to be sedated. Is it possible she will stay psychotic?
Mon, 1 Jul 2013
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Diabetologist 's  Response
DEAR SIR/MADAM

HALODOL CONTAINS HALOPERIDOL IS DOPAMINE INVERSE AGONIST WHICH IS USED TYPICALLY FOR TREATMENT FOR PSYCHOSIS AND HALLUCINATIONS, USUALLY THESE DRUGS WILL CAUSE REVERSE DEPRESSION WHEN TAKEN FOR A LONG TIME.
SEDATION IS NOT NEEDED, TRY TO CONULT YOUR PSYCHIATRIST AND CHANGE THE GROUP OF DRUGS TO TRICYCLIC ANTIDEPRESSANTS AND SEE FOR SOME TIME.

THANKS
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Psychiatrist Dr. Anjana Rao Kavoor's  Response
Hi.

Haloperidol is a 1st generation antipsychotic drug used to treat psychosis. Psychosis includes hallucinations, delusions as well as gross phycho-motor agitation (might manifest as aggression). Normally poor self care (eating very less) and sleep disturbances accompany psychosis.
Seroquel is quetiapine, a newer antipsychotic with much better side effect profile compared to haloperidol, though certain metabolic side effects like disturbance of blood sugar levels etc. are more.

now if your mother has developed psychosis at the age of 75 years, it is most likely a manifestation of some underlying organic pathology. At this age, she needs to be investigated thoroughly on these lines by neuroimaging, blood biochemistry etc., and then managed according to the findings. The symptoms are likely to improve if the underlying issues are addressed. However, prognosis may be guarded.

Hope this helps.
Dr. A. Rao
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Psychiatrist Dr. Sundar Gnanavel's  Response
Hello......
Thanks for your query. The choice of quetiapine as an antipsychotic is apt considering it is a new generation antipsychotic with minimum propensity for extrapyramidal side effects unlike older drugs like haloperidol. If the response to quetiapine has plateaued off, you can discuss with your psychiatrist for an escalation of dosage of quetiapine. Do not lose hope at this stage. We have an armamentarium of drugs including clozapine for resistant psychosis. Wish her good health.
Regards
Dr Sundar
Psychiatrist
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Having Psychosis And Dementia.Was On Haldol, Now Seroquel. Is It Possible She Will Stay Psychotic?

DEAR SIR/MADAM HALODOL CONTAINS HALOPERIDOL IS DOPAMINE INVERSE AGONIST WHICH IS USED TYPICALLY FOR TREATMENT FOR PSYCHOSIS AND HALLUCINATIONS, USUALLY THESE DRUGS WILL CAUSE REVERSE DEPRESSION WHEN TAKEN FOR A LONG TIME. SEDATION IS NOT NEEDED, TRY TO CONULT YOUR PSYCHIATRIST AND CHANGE THE GROUP OF DRUGS TO TRICYCLIC ANTIDEPRESSANTS AND SEE FOR SOME TIME. THANKS