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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Heavy Bleeding, Epileptic, Endometriosis, Hysterectomy, Oophorectomy. On Depakote. Advice?

Hi, I am an epileptic and have been for 13 years. I was prescribed Depakote 500 mg twice a day. When I started menstrating, I noticed that I had a heavy and not natural flow. Because of that I was prescribed with Ortho Tri Cyclin. Recently, I was diagnosed with Stage 4 Endometriosis and had to have a complete Hysterectomy and Oophorectomy. I did some research and no one in my family has or has had Endometriosis. My question is this. If Depakote and certain birth control medications are mixed, can that cause things like Endometriosis?
posted on Wed, 16 Oct 2013
Twitter Wed, 16 Oct 2013 Answered on
Twitter Thu, 17 Oct 2013 Last reviewed on
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OBGYN,  's  Response
Hi,
welcome to HCM.

I understand your concern as many drugs do interact and lead to newer diseases. However, endometriosis is an enigmatic disease for the gynecologists even in this advanced era. The exact reason as to why it develops is not known. The risk factors like having a family history, or not having children only increase the chance of having endometriosis but it does not mean that other women will not develop this disease. Oral contraceptives like ortho tri are used as one of the simple ways to treat endometriosis and actually help in decreasing the disease.

There is no available literature as far as my knowledge is concerned and even in my clinical practice I have never encountered a patient who has taken antiepileptics and Oc's together to have developed endometriosis.

Hope this is of help and please do not worry.
Thanks for using HCM.
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Heavy Bleeding, Epileptic, Endometriosis, Hysterectomy, Oophorectomy. On Depakote. Advice?

Hi, welcome to HCM. I understand your concern as many drugs do interact and lead to newer diseases. However, endometriosis is an enigmatic disease for the gynecologists even in this advanced era. The exact reason as to why it develops is not known. The risk factors like having a family history, or not having children only increase the chance of having endometriosis but it does not mean that other women will not develop this disease. Oral contraceptives like ortho tri are used as one of the simple ways to treat endometriosis and actually help in decreasing the disease. There is no available literature as far as my knowledge is concerned and even in my clinical practice I have never encountered a patient who has taken antiepileptics and Oc s together to have developed endometriosis. Hope this is of help and please do not worry. Thanks for using HCM.