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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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How A Medicine Work On Non Insulin Dependent Diabetes Mellitus [NIDDM]?

how a medicine work in niddm/
posted on Sat, 30 Oct 2010
Twitter Mon, 1 Nov 2010 Answered on
Twitter Sat, 21 Jul 2012 Last reviewed on
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General & Family Physician,  's  Response
Welcome to Health Care Magic Diabetic forum:

Metformin stimulates the insulin-induced component of glucose uptake into skeletal muscle and adipocytes in both diabetic individual (by pushing glucose from into skeletal muscles and fat tissue it decreases blood glucose levels).

Sulfonylurea binds to cells in Pancreas (called β-cells) and induces release of insulin into blood. Insulin ultimately decreases blood glucose.

TDZs (Actos and Avandia) has complex mechanism. They act on nuclear receptors called PPAR gamma. It results in alteration in the expression of genes involved in fat and glucose metabolism. Finally they increases insulin sensitivity, meaning Insulin action is increased on muscles and skeletal muscles
Good luck- Dr. Jagdish
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How A Medicine Work On Non Insulin Dependent Diabetes Mellitus [NIDDM]?

Welcome to Health Care Magic Diabetic forum: Metformin stimulates the insulin-induced component of glucose uptake into skeletal muscle and adipocytes in both diabetic individual (by pushing glucose from into skeletal muscles and fat tissue it decreases blood glucose levels). Sulfonylurea binds to cells in Pancreas (called β-cells) and induces release of insulin into blood. Insulin ultimately decreases blood glucose. TDZs (Actos and Avandia) has complex mechanism. They act on nuclear receptors called PPAR gamma. It results in alteration in the expression of genes involved in fat and glucose metabolism. Finally they increases insulin sensitivity, meaning Insulin action is increased on muscles and skeletal muscles Good luck- Dr. Jagdish