My wife is experiencing significant quality of life reduction issues that appear to be direct side effects of Letrozole, her AI treatment that is being projected as a 5 year treatment. Being that her breast cancer was characterized as small, benign, and early Stage 1 with successful partial mastectomy with clear margin and then subsequent radiation treatment - what are the statistical advantages of her continuing the Letrozole treatments and having to put up with the quality of life reduction? Said differently, if she chooses to discontinue the Letrozole in exchange for higher quality of life now, what is the statistical risk penalty that she is taking on for this immediate relief?