Vaginal irritation will often get better on its own. However, if the irritation continues, is severe, or comes back after treatment, call for an appointment with your doctor. The doctor can do a pelvic exam. The doctor will probably also take a sample of the discharge to find the source of the problem. How vaginal discomfort is treated depends on what condition is causing the problem: Vaginosis and STDs are treated with antibiotics/antiparasitics. Yeast infections are treated with antifungal medications. They are inserted into the vagina in the form of creams, ointments, or suppositories, or they are taken orally. You can buy these medications over the counter in different doses -- one-day, three-day, seven-day. However, if you ve never been diagnosed with a yeast infection, see your doctor before taking any over-the-counter medication. Menopause-related itching may be treated with estrogen cream, tablets, or a vaginal ring insert. Other types of itching and irritation respond to steroid creams or lotions, which reduce inflammation. A prescription-strength steroid cream can relieve the irritation of lichen sclerosis.