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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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How Can Severe Mania Be Treated?

Yes, my sister is in an acute manic state: pressured speech, grandiosity, paranoia, inappropriate humor, out of touch with reality, etc. She just started on Divalproex, 250 mg. How long will it take to take effect. ??How fast can it be titrated up? What s the therapeutic dose for a 69 year old woman of 5 ft , 116 lbs?
posted on Sun, 4 Mar 2018
Twitter Tue, 26 Jun 2018 Answered on
Twitter Thu, 28 Jun 2018 Last reviewed on
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Psychiatrist,  's  Response
Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice.

If it's an acute episode of mania, it probably cannot be controlled by 250mg. If it is uncontrollable, getting admitted under supervision of a Psychiatrist and administering injectable antipsychotics is also preferable.

You can escalate gradually based on her response to medication.
Avoid sedatives.

I hope I have answered your query. Feel free to ask further questions.
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How Can Severe Mania Be Treated?

Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. If it s an acute episode of mania, it probably cannot be controlled by 250mg. If it is uncontrollable, getting admitted under supervision of a Psychiatrist and administering injectable antipsychotics is also preferable. You can escalate gradually based on her response to medication. Avoid sedatives. I hope I have answered your query. Feel free to ask further questions.