hello and thank ou for asking HCM, I understand your concern. These are the most common symptoms of an enlarged spleen: - being unable to eat a large meal - feeling discomfort, fullness, or pain on the upper left side of the abdomen; this pain may spread to your left shoulder - if you have pain that is severe or gets worse when taking a deep breath, see your doctor right away If you have an enlarged spleen, you may develop other signs or symptoms, too. These are related to the underlying disease. They may include signs and symptoms such as: Fatigue, weight loss, frequent infections, easy bleeding, jaundice, anemia I hope this answer was helpful to you.