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How To Interpret Blood Test Result?
I am a 62 year-old female dx’d with Monoclonal b-cell Lymphocytosis 2 yrs ago. My latest blood work shows the following:
1. lymphocytes trending upward from 3.5 to 5.3 over the 2 yrs;
2. neutrophils ranging from 2.8 – 4. 1 but latest showed drop to 1.57;
3. first appearance of a few smudge cells and a few ovalocytes;
4. slightly elevated RDW in the last 2 reports to 15.8.
All my other counts are normal. No organomegaly, adenopathy, fever, night sweats, etc. My doctor is not worried about these numbers and says I am still MBL (b cells are still
My question is this: do these latest results represent a progression of disease or is this just normal expected variation? I understand that MBL only rarely progresses to CLL but I am concerned with the slow steady increase in lymphocytes and the first indications that there may be something amiss with my red cell production.
Thank you kindly.
1. lymphocytes trending upward from 3.5 to 5.3 over the 2 yrs;
2. neutrophils ranging from 2.8 – 4. 1 but latest showed drop to 1.57;
3. first appearance of a few smudge cells and a few ovalocytes;
4. slightly elevated RDW in the last 2 reports to 15.8.
All my other counts are normal. No organomegaly, adenopathy, fever, night sweats, etc. My doctor is not worried about these numbers and says I am still MBL (b cells are still
My question is this: do these latest results represent a progression of disease or is this just normal expected variation? I understand that MBL only rarely progresses to CLL but I am concerned with the slow steady increase in lymphocytes and the first indications that there may be something amiss with my red cell production.
Thank you kindly.
Mon, 12 Jan 2015
Hello and welcome to HCM,
An increase in lymphocytes and presence of smudge cells in background of monoclonal B-cells suggests upgradation of the disease.
The total white cell count is also required to assess the clinical status.
The presence of ovalocytes suggests presence of macrocytic anemia.
Elevated RDW suggests presence of variation in sizes of red blood cells.
Variation in red blood cells is seen in anemia.
Consult your hematologist with the current report for further management.
Thanks and take care
Dr Shailja Puri
An increase in lymphocytes and presence of smudge cells in background of monoclonal B-cells suggests upgradation of the disease.
The total white cell count is also required to assess the clinical status.
The presence of ovalocytes suggests presence of macrocytic anemia.
Elevated RDW suggests presence of variation in sizes of red blood cells.
Variation in red blood cells is seen in anemia.
Consult your hematologist with the current report for further management.
Thanks and take care
Dr Shailja Puri
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