hello rajesh, i can understand the pain you are going through. 15 years is a very long time. alopecia areata is a very common disorder but most of the patients recover either on their own or with medicines within months. in few patients the disease is long standing. most of these patients have an associated disorder like hypothyroidism. these patients improve once i put them on thyroid medicines. i suggest you to get the following tests done: 1. S.TSH 2. S.free T3 3. S. free T4 4. antithyroglobulin antibodies 5. anti TPO antibodies the twice weekly regimen of betnesol is the most accepted regimen for alopecia areata. tab azoran is also an immunosuppresant and will add to the effect. i would suggest you to also apply tacrolimus 0.1% lotion daily at effected areas. alopcia areata is an autoimmune disease and as with any other autoimmune disease the course cannot be predicted. we can give you the best advise available. hope this answer helps. get back to us for any further queries. thanks.