Hello and welcome to HCM, Cysts on labia majora and on leg appear to be primary skin blistering lesion. Photograph of the cysts would be more helpful to determine the nature of the cysts. Cysts are known to occur on labia due to enlargement of Bartholins gland and these enlarged glands often get infected. However, concurrent cyst on leg rule out the possibility of enlargement of Bartholins gland. Since, the cysts are painful, infection is probable and thus a course of antibiotic needs to be taken to control the infection. However, clinical assessment by your primary healthcare provider needs to be done to diagnose and then prescribe the drugs. Thanks and take care Dr Shailja Puri Pain in the cysts suggest that these lesions have become infected.