Hello and welcome to Ask A Doctor services. I have read your query and here is my advise. * The irritable bowel syndrome with Parkinsonism and atrial fibrillation needs specific attention over and above intake of Pan tablet - avoid consumption of warfarin and ecosprin together and also on empty stomach - avoid stress and anxiety - involve in regular aerobics and walking or swimming ( if involved ) - drink more amount of liquids - do take high fiber diet with plenty of greens, cereals, whole grains, legumes, bran, yogurt - avoid all sort of spices, excess sugary, fat and cholesterol items which slow down the digestion - bulk forming laxative as Ispaghula or Psyllium husk - avoid smoking or alcohol if consuming - avoid aerated drinks and caffeine - avoid intake of lunch and supper to full appetite, rather keep the stomach empty by 25 % of satiety values - consume frequent , small feeds - chew your food very thoroughly * Remain in regular follow up with your doc. Thank you. Dr Bhagyesh ( MS consultant surgeon )