Dear user, in general minimal change disease is a very responsive disease, especially to steroids. If it does not, there is something wrong. First, the problem may be a too rapid tapering. Second, renal biopsy often cannot rule out an FSGS, which is a podocitopathy as MCD, but much more resistant. Third, make sure your nephrologist did a screening of secondary causes, which are many, and may explain this kind of resistance. Fourth, there are a number of second line approaches, in particular cyclosporine, which may be effective in steroid resistant forms. Fifth, you need lot of patience...make sure to reduce salt and liquid intake, reduce protein intake to less than 1 g/kg/day and have a daily weight in order to avoid fluid excess. Avoid NSAIDs and every nephrotoxic drug. Best regards, Andrea