Hello Thanks for query. Based on information that you have provided it seems that you have problem of Erectile Dysfunction which is vasculogenic in origin and have been prescribed drugs like nano Leo and Fludac , To my knowledge these drugs are not going to improve blood flow to cavernous tissue and helps to resolve the problem of ED. Recently a new technology called as Low Intensity Shock Wave Therapy (LI-ESWT)to cavernous tissue has come which increases blood flow to erectile tissue and helps to resolve the issue of ED. Though it is expensive the clinical trial at many centers have found it to be very effective in improving and resolving the problem of ED on long term basis . Dr.Patil