I have been taking Lyrica for CRPS. I started on 50mg pills, tritating up to 200mg a day. I was still having pain so my doctor decided to increase my dosage. We increased to 300mg a day and I was supposed to tritate up to 450mg per day. But about a week into the 300mg a day and two days of 350mg, I started swelling (I.e. fluid retention) all over. Worst was my legs, ankles and feet. My CRPS is in my left leg from my hip to the tips of my toes, so the swelling is making me hurt worse again. I thought it was the Lyrica so I stopped taking it as of Thursday night. All my doctor said was that I could lower the Lyrica dose, "if I wanted to." The swelling hasn't gone down much so now I'm questioning if it was the higher dose of Lyrica.