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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is Clomiphene The Right Medication To Treat Pubertal Gynaecomastia?

I was reading a case study on a 16 year old male that had no deepening of his voice, scanty pubic and axillary hair growth, absence of beard and mustache growth, small penis, poor muscular development, and psychosocial immaturity. He was given Clomiphene 100mg/day for seven days. Was wondering if Clomiphene was given to treat pubertal gynecomastia? Wasn t sure the reason for giving the boy a medication that stimulates ovulation in females.
Wed, 22 Apr 2015
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General & Family Physician,  's  Response
Hi
Thanks for posting your query on HCM.
I appreciate your concern for the case of 16 yrs old male with gynecomastia.

Yes, Clomiphene is the right medication to treat pubertal gynecomastia.

At puberty some boys produce slightly higher amounts of female hormones known as estrogens. As a result of this an imbalance between male hormones (androgens) and female hormones (estrogens) occurs and the female body characteristics like breasts (gynecomastia)and other bodily and physiological features develop in males.

Absence of beard and moustache, small penis and poor muscular development occurs because of low levels of male hormones.

Clomiphene citrate which is mainly used in the treatment of female infertility because of its ovulation stimulation effect is also found to be useful in reducing the high levels of estrogens in males as in case of pubertal gynecomastia, hence it is used.

Tamoxifen (basically used in the treatment of breast cancer) is another drug which has similar actions as that of Clomiphene is also used in the treatment of pubertal gynaecomastia.
The side effects of Climiphene in males include rash, nausea or visual disturbances.
Hope this answers your query.

A feed back is appreciated.
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Is Clomiphene The Right Medication To Treat Pubertal Gynaecomastia?

Hi Thanks for posting your query on HCM. I appreciate your concern for the case of 16 yrs old male with gynecomastia. Yes, Clomiphene is the right medication to treat pubertal gynecomastia. At puberty some boys produce slightly higher amounts of female hormones known as estrogens. As a result of this an imbalance between male hormones (androgens) and female hormones (estrogens) occurs and the female body characteristics like breasts (gynecomastia)and other bodily and physiological features develop in males. Absence of beard and moustache, small penis and poor muscular development occurs because of low levels of male hormones. Clomiphene citrate which is mainly used in the treatment of female infertility because of its ovulation stimulation effect is also found to be useful in reducing the high levels of estrogens in males as in case of pubertal gynecomastia, hence it is used. Tamoxifen (basically used in the treatment of breast cancer) is another drug which has similar actions as that of Clomiphene is also used in the treatment of pubertal gynaecomastia. The side effects of Climiphene in males include rash, nausea or visual disturbances. Hope this answers your query. A feed back is appreciated.