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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is Limb-girdle Muscular Dystrophy Disease Hereditary?

Hello Doctor,
My daughter is reported of having Lgmd, aged about 11 years.
I want to know whether this decease is heriditary? i.e. this disorder may be transformed to next baby i.e. deceased's brother or sister(yet to be expected)
Pl. reply me what shall I do at this stage?
Thanks and regards,
SPN. KANAGARAJ,
Mobile: 0091 0000
Email: YYYY@YYYY
Thu, 28 Aug 2014
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Ayurveda Specialist 's  Response
Your anxiety is really justifiable...

LGMD is a genetic disorder having mutations on some genes...

Usually LGMD is seen in its autosomal recessive form. Let me explain - When either one of the parent is having the having the mutation for this disorder on his or her gene the child may not suffer from the condition however becomes dominant if both the parents are carrier of the same mutation on their genes... Now coming to next child option.. the disorder unlike Duchenne Muscular Distrophy is not gender biased and thus can be seen equivalent in both the genders.

But keep hope as both the parents carry 2 copies of genes set and we really don't know that which one copy is going to inherit so the chances becomes 50% for the next child.

You are having options to get prenatal diagnosis for the expected child where the expected child is either suffering from the disorder or not..

About your daughter I will say that Physiotherapy is a best option for her... And, you can consult to Dr.Manohar Gundeti from Ayurveda Cancer Research Institute, (CCRAS, Govt. of India) Mumbai. Who has treated some cases of Muscular Dystrophies for the supportive line of treatment and better prognosis of your child.

I hope the information given is enough helpful for you..
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Note: For detailed guidance on genetic screening consult a genetics specialist
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Is Limb-girdle Muscular Dystrophy Disease Hereditary?

Your anxiety is really justifiable... LGMD is a genetic disorder having mutations on some genes... Usually LGMD is seen in its autosomal recessive form. Let me explain - When either one of the parent is having the having the mutation for this disorder on his or her gene the child may not suffer from the condition however becomes dominant if both the parents are carrier of the same mutation on their genes... Now coming to next child option.. the disorder unlike Duchenne Muscular Distrophy is not gender biased and thus can be seen equivalent in both the genders. But keep hope as both the parents carry 2 copies of genes set and we really don t know that which one copy is going to inherit so the chances becomes 50% for the next child. You are having options to get prenatal diagnosis for the expected child where the expected child is either suffering from the disorder or not.. About your daughter I will say that Physiotherapy is a best option for her... And, you can consult to Dr.Manohar Gundeti from Ayurveda Cancer Research Institute, (CCRAS, Govt. of India) Mumbai. Who has treated some cases of Muscular Dystrophies for the supportive line of treatment and better prognosis of your child. I hope the information given is enough helpful for you..