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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is Nifedipine A Good Substitute Of Isosorbide Mononitrate?

Hello My father has been taking isosorbide mononitrate ER for a few years now. For his angina. This time when he got his refill, he received Nifedipine instead (the pill is imprinted with KU 260 ). He is also taking Metoprolol, Aspirin, Losartan, Atorvastatin, Metformin and Avodart. Is the Nifedipine an appropriate substitute for the Isosorbide Mononitrate? My father is 68 years old. Thank you
posted on Tue, 5 Dec 2017
Twitter Tue, 26 Dec 2017 Answered on
Twitter Wed, 27 Dec 2017 Last reviewed on
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General & Family Physician,  's  Response
Oesophageal motor activity was recorded manometrically with a low compliance system in 16 patients with achalasia and a slightly dilated oesophagus. After a basal recording period, nifedipine 20 mg was given sublingually to 9 patients and isosorbide dinitrate 5 mg to another 7 patients. Lower oesophageal sphincter pressure (LESp) and oesophageal body pressure wave amplitude were measured for 60 min after drug administration. Both drugs decreased LESp and pressure wave amplitude, but the effect of isosorbide dinitrate was faster and more intense than that of nifedipine. There was a lower inhibitory effect of nifedipine on the amplitude of pressure waves than on LESp, while isosorbide dinitrate inhibited with a similar intensity both LESp and pressure waves...

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Is Nifedipine A Good Substitute Of Isosorbide Mononitrate?

Oesophageal motor activity was recorded manometrically with a low compliance system in 16 patients with achalasia and a slightly dilated oesophagus. After a basal recording period, nifedipine 20 mg was given sublingually to 9 patients and isosorbide dinitrate 5 mg to another 7 patients. Lower oesophageal sphincter pressure (LESp) and oesophageal body pressure wave amplitude were measured for 60 min after drug administration. Both drugs decreased LESp and pressure wave amplitude, but the effect of isosorbide dinitrate was faster and more intense than that of nifedipine. There was a lower inhibitory effect of nifedipine on the amplitude of pressure waves than on LESp, while isosorbide dinitrate inhibited with a similar intensity both LESp and pressure waves... I hope you happy with information kindly rate it. thank you.