Hello Ocid-D i.e. omeprazole-domeperidone is very much effective in gastritis or hyperacidity . As you mentioned that you are having burning sensation , feeling of fullness in upper abdominal area ( epigastrium ) and loss of appetite. Naturally hyper acidity or fullness in abdomen causes loss of appetite. Do following measures , you will get some relief. Try raising the head of your bed about 4 inches with blocks. It also might help to avoid eating or drinking for 2 hours before you lie down. To help control stomach acid one should not drink alcohol or drinks with caffeine in them or excessive tea or eat chocolates or spicy or greasy foods. As you mentioned that you are taking ocid - d , its a very good drug. If symptoms are severe them you may need some antacid syrup which contains oxetacaine ( for instant relief). 2 Over eating is one of the most important reason of such symptoms , so please avoid . For loss of appetite you can take buclizine hydrochloride syrup 2-3 TSF before each meal. Ocid - d be taken on empty stomach. Take these drugs till complete relief. For IBS consult your treating physician. Good luck.