** Thanks for contacting with your health concern 1. Prolia [denosumab] is a human monoclonal antibody for the treatment of osteoporosis and giant cell tumor of the bone and contraindicated in people with low blood calcium [check with the calcium values] 2. since it can cause severe pain in joints/bones [and you have the history of osteoarthritis which is regulated] thus can flare up the condition, but since it is given only once 6 months I don t think it will be of much concern, however, talk to your attending Physician regarding the same. PS. also with prolia, dental hygiene is a must [as osteonecrosis of jaw] is common, so regular dental checkup is advisable. 3. So if interested in using prolia be under the regular supervision of your attending physician since he/she will be in better position to alleviate the symptoms when arisen. 4. I at most can let you know about the preventive aspect of Osteoporosis: i. going by your age [61], the condition fits under Primary Osteoporosis: Post Menopausal [Type I] and progressing to Senile [Type II] ii. Preventive Aspect: . Calcium intake; 1.0-1.5 g per day [banana, grapes,coriander, raisins, milk, green vegetables, lemon,mint,papaya,amla,guava, pineapple,turnip, tomato, apple,orange. . Moderate Vitamin D intake: 400-800 IU per day or calcitriol 0.25~g/day [ carot, beetroot,spianch,radish,mint,amalaki rasayan,soyabean,cucumber, cabbage,vitamin D fortified: pineapple/yogurt/milk/dry mushroom/banana/ cod liver oil/sunshine. . Periodic assessment of skeletal status and bone mineral. . Single Drug which is extremely helpful and beneficial in postmenopausal osteoporosis is Shatavari which can be explained with the help of its active chemical constituent- Steroidal Saponins which are Phytoestrogens. Phytoestrogens act as SERM s [selective estrogen receptors modulators] and stimulate osteoblastosis and suppress osteoclastosis and thus help in preventing bone loss. PS. In modern medicine they also have SERM s [raloxifene, idoxifene, tamoxifene], the action is similar as described.