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Dr. Andrew Rynne
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Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is Trivenz The Right Medication To Prevent HIV Infection After Unprotected Sex With Someone Who Tested Positive?

I met a lady and she sent to me her HIV kit result which was negative and I also did mine and sent it to her. We had unprotected sex and after that I insisted we redo the test. Unfortunately her result came out positive and mine negative. I am went to the pharmacy where I got trivenz to prevent me from possible infection. Is this the right medication?
posted on Tue, 10 Oct 2023
Twitter Fri, 8 Aug 2025 Answered on
Twitter Mon, 1 Sep 2025 Last reviewed on
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General & Family Physician,  's  Response
Hello,

Trivenz is used as antiretroviral therapy (ART) for people who are already HIV-positive. While it contains two of the right drugs for PEP (post-exposure prophylaxis), efavirenz, the third ingredient is not recommended for PEP because of its neuropsychiatric side effects and reduced tolerability.

If the unprotected sex was within 72 hours, you need PEP. However, before taking PEP, you already have a negative test but also get liver and kidney function test done as PEP affects these organs. PEP is advised to be started within 72 hours of exposure and taken correctly for 28 days. It is very effective (over 90%) at preventing HIV infection.

However, follow-up HIV testing is needed at 6 weeks, 12 weeks and sometimes 6 months after exposure. Trivenz is not the correct medication for HIV prevention after exposure. You are advised to visit an HIV clinic or HIV specialist. You have to take PEP, take Tenofovir, Emtricitabine, Dolutegravir or Raltegravir within 72 hours of exposure, for 28 days.

Take care. Hope I have answered your question. Let me know if I can assist you further.

Regards,
Dr. Nupur K., General & Family Physician
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Is Trivenz The Right Medication To Prevent HIV Infection After Unprotected Sex With Someone Who Tested Positive?

Hello, Trivenz is used as antiretroviral therapy (ART) for people who are already HIV-positive. While it contains two of the right drugs for PEP (post-exposure prophylaxis), efavirenz, the third ingredient is not recommended for PEP because of its neuropsychiatric side effects and reduced tolerability. If the unprotected sex was within 72 hours, you need PEP. However, before taking PEP, you already have a negative test but also get liver and kidney function test done as PEP affects these organs. PEP is advised to be started within 72 hours of exposure and taken correctly for 28 days. It is very effective (over 90%) at preventing HIV infection. However, follow-up HIV testing is needed at 6 weeks, 12 weeks and sometimes 6 months after exposure. Trivenz is not the correct medication for HIV prevention after exposure. You are advised to visit an HIV clinic or HIV specialist. You have to take PEP, take Tenofovir, Emtricitabine, Dolutegravir or Raltegravir within 72 hours of exposure, for 28 days. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Nupur K., General & Family Physician