Hi, Thanks for asking. Based on your clinical history and query, my opinion is as follows: 1. Yes, repeated sickling/ sickle crisis permanently deforms the RBCs, which cannot regain its original discoid shape after cessation of crisis. 2. Deformed RBCs cannot pass through the splenic microcirculation which can lead to dreaded consequences like hypoxia and autosplenectomy. 3. Hemolysis is also known to occur with this situation worsening the anemia. 4. Yes, you need to get a consultation and appropriate treatment. Hope it helps. Any further queries, happy to help again.