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Dr. Andrew Rynne
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Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is Paxil And Klonopin A Good Combination For Depression?

Hi, I just switched from ativan to klonopin 3 weeks ago and am even more depressed than before. I tried effexor and liked it but, I have low bp and high heart rate when I stand POTS syndrome. The effexor makes my hr go up a lot more, 3rd day standing hr was 170. The Dr. Started me out at 150mgs. The only drug I have had luck with has been paxil at 30mgs. Are paxil and Klonopin a good mix? I also read that K decreases seratonin, is this true? If so, should paxil be able to pull me out of the terrible mood I'm in, crying, fearful ect? I'm hoping that the Paxil will kick in and I can start weaning the 1mg I am taking of K. My psych said the Ativan was giving me paridoxical effect after 8 months. I feel the K is doing that too so I want to get off at some point. Thank you!! Brooke
posted on Sat, 15 Mar 2014
Twitter Sun, 23 Mar 2014 Answered on
Twitter Tue, 25 Mar 2014 Last reviewed on
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Psychiatrist,  's  Response
Hello and welcome to HCM
The combination of paxil and klonopin is fine but --it should give good results to you too!. It is not that every patient will have good results with a particular combination.
In cases like yours - you have some results with paxil 30 mg , so i think it will be good that you incresase the dosage further to 45-50mg daily.

If you adequte response then its ok, but if there is not adequate response- then i have had very good results in such cases by adding quetiapine . Quetiapine not only controls anxiety/sadness but also give well deserved seation. It reduces the need to take klonopin to a large extent.
so, please meet your pschatrist and discuss these points.

I hope the reply helps you
Feel free to ask more queries

Dr. Manisha Gopal
MD Psychiatry
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Is Paxil And Klonopin A Good Combination For Depression?

Hello and welcome to HCM The combination of paxil and klonopin is fine but --it should give good results to you too!. It is not that every patient will have good results with a particular combination. In cases like yours - you have some results with paxil 30 mg , so i think it will be good that you incresase the dosage further to 45-50mg daily. If you adequte response then its ok, but if there is not adequate response- then i have had very good results in such cases by adding quetiapine . Quetiapine not only controls anxiety/sadness but also give well deserved seation. It reduces the need to take klonopin to a large extent. so, please meet your pschatrist and discuss these points. I hope the reply helps you Feel free to ask more queries Dr. Manisha Gopal MD Psychiatry