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Dr. Andrew Rynne
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Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is Strong Musky Smell In Urine Normal While Taking Methotrexate?

My name is Judy. My question has to do with a strong urine smell. I never noticed it before. I am 170 lb. 67 yes. Taking Methotrexate for RA. Taking 6-2.5 mg tablets every Friday w breakfast. Started April 10th. Have noticed a strong musky smell in urine. Is that to be expected¿
posted on Tue, 12 May 2015
Twitter Mon, 25 Apr 2022 Answered on
Twitter Thu, 28 Apr 2022 Last reviewed on
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Cardiologist,  's  Response
Hello,

The smell in the urine is a common adverse effect of Methotrexate. I recommend taking folic acid to reduce the smell and performing a urine bacterial culture, just to be sure that there is no infection.

Take care. Hope I have answered your question. Let me know if I can assist you further.

Regards,
Dr. Ilir Sharka, Cardiologist
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Is Strong Musky Smell In Urine Normal While Taking Methotrexate?

Hello, The smell in the urine is a common adverse effect of Methotrexate. I recommend taking folic acid to reduce the smell and performing a urine bacterial culture, just to be sure that there is no infection. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Ilir Sharka, Cardiologist