Get your health question answered instantly from our pool of 18000+ doctors from over 80 specialties
159 Doctors Online

By proceeding, I accept the Terms and Conditions

Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

HCM Blog Instant Access to Doctors
HCM BlogQuestions Answered
HCM Blog Satisfaction

Is Taking Spironolactone At 4am Most Effective For Reducing Androgens Considering That It Reaches Peak Absorption 4 Hours After Administration?

Hi, I am taking spironolactone to reduce the excess androgens and associated symptoms of polycystic ovary syndrome. I have been told I can either take it day or night and I have tried both times which have been fine in terms of having minimal side effects. I was just wondering which time of day might be most effective for reducing androgens? I heard that androgens have a pattern of secretion that means they raise steadily over the night and peak between 7-10am. I also heard that spironolactone reaches peak absorption around 4 hours after oral administration. Would this mean that taking spironolactone at around 4am would be the best for reducing androgens? Or it is perhaps not that simple? I couldn t find any studies investigating this. Thank you. Kind regards
posted on Tue, 1 Aug 2023
Twitter