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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is There Interaction Between Losartan And NSAIDs?

What is the mechanism of action of the interaction between Losartan and NSAIDs? It seems to me that most warnings about this interaction are very general, and based on the fact that Losartan is (somewhat) kidney protective in Diabetes Type II. If I am taking Losartan for uncomplicated hypertension and do not have kidney disease or diabetes, should I worry about this interaction?
Tue, 31 Dec 2019
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General & Family Physician,  's  Response
Hi,

Kidneys produce certain chemical substances called prostaglandins (PGE2 and PGI2) which normally increase the kidney blood flow and take part in the important functions of the kidneys.

These beneficial prostaglandins are also essential to mediate the blood pressure lowering effects of anti-hypertensive drugs such as Losartan.

Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or diclofenac act by blocking the production of 'kidney protective' PGE2 and PGI2 thereby producing kidney damage.

Losartan is an angiotensin receptor blocker commonly prescribed to treat high blood pressure. Indeed, it is a kidney protective drug in type 2 diabetes.

If Losartan is given along with NSAIDs, they reduce the blood pressure lowering effects of Losratan and therefore blood pressure may not be controlled effectively.

Even if you take NSIADs along with Losartan along without actually suffering from diabetes or kidney disease, your blood pressure may not be controlled as explained above, so avoid taking NSAIDs as long as you take Losartan.

Hope I have answered your query. Let me know if I can assist you further.

Take care

Regards,
Dr. Mohammed Taher Ali, General & Family Physician
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Is There Interaction Between Losartan And NSAIDs?

Hi, Kidneys produce certain chemical substances called prostaglandins (PGE2 and PGI2) which normally increase the kidney blood flow and take part in the important functions of the kidneys. These beneficial prostaglandins are also essential to mediate the blood pressure lowering effects of anti-hypertensive drugs such as Losartan. Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or diclofenac act by blocking the production of kidney protective PGE2 and PGI2 thereby producing kidney damage. Losartan is an angiotensin receptor blocker commonly prescribed to treat high blood pressure. Indeed, it is a kidney protective drug in type 2 diabetes. If Losartan is given along with NSAIDs, they reduce the blood pressure lowering effects of Losratan and therefore blood pressure may not be controlled effectively. Even if you take NSIADs along with Losartan along without actually suffering from diabetes or kidney disease, your blood pressure may not be controlled as explained above, so avoid taking NSAIDs as long as you take Losartan. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr. Mohammed Taher Ali, General & Family Physician