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Lab Report Shows Asthenoteratozoospermia Based On Total Ejaculate Concentration, Motility And Morphology. Explain
HI...
PLEASE GO THROUGH THIS REPORT AND HELP ME IN THIS REGARD...
ADVANCED ANDROLOGY LABORATORY
COMPUTER ASSISTED SPERM ASSESSMENT (CASA)
Name MR. SURESH KUMAR.S Age 34 Yrs Hosp No
Abstinence days 03 Volume → 2.6 ml
Time of Collection 09.40 AM Time of Evaluation 10.10 AM Spillage: No
Fructose → Positive Pus cells→ 01/hpf Not Significant Ph → 8.0 Liquefaction → Normal Live → 39 % Dead → 61 %
CONCENTRATION ASSESSMENT (5th percentile value)
Total Ejaculate
Millions 218 million
Total Ejaculate: Normal
(5th per: 40 75th per: 120)
Sperm Conc.
(millions / ml 84 mill/ml
MOTILITY ASSESSMENT (5th percentile value)
Sperm Motility 1 Hr 2 Hrs
Total Progressive 27% 12%
Non Progressive 08% 10%
Immotile 65% 78%
Total motility
(Total Progressive + Non Progressive) 35% 22 %
1 Hour Total motility: Sub Normal
(5th Per: 42 75th Per: 50)
Advanced CASA parameters Micro mt/sec
Straight Line Velocity-VSL 00.0
Curvilinear Velocity –VCL 28.0
Hyper activation –H max assay 00.0
Advanced Total Progressive Motility Assessment (CASMA)
Rapid Progressive 00%
Slow Progressive 27%
Advanced Total progressive motility: Sub Normal
(5th Per: 10 75th Per: 15)
MORPHOLOGY ASSESSMENT (TYGERBERG KRUGER) (5th percentile value)
Morphology %
Normal Forms 02%
Over all Defects 98%
Sperm Morphology: Sub Normal
(5th Per: 4 75th Per: 9)
Head Defects 67%
Mid Piece and Neck Defects 20%
Tail Defects 11%
Multiple Defects 33%
Excessive residual cytoplasm (ERC) 03%
Ex. residual cytoplasm: Not Significant
ADVANCED ANDROLOGY LABORATORY
ADDITIONAL PARAMETER ASSESSMENT
Round cells: Nil Bacteria: Not significant
RBC: Nil Agglutination: Nil Cellular debris: Not significant
Special Comment :
Final Impression- ASTHENOTERATOZOOSPERMIA
1. Terminology used in final impression is on the basis of total ejaculate concentration, motility & morphology. Additional parameter reported needs to be evaluated independently by the physician.
2. Impression based on 5th percentile value, however, 75th percentile value may be optimum and treatment plan may be suitably
decided by the physician.
3. 75th percentile value was decided optimum instead of 90th percentile by our clinical database and international opinion - to avoid too large an indeterminate group.
CASA: Computerised semen analysis is done with sperm class analyzer (http://www.spermclassanalyzer.com/) which provides fast, accurate & objectively repeatable results. This sophisticated software reports concentration, motility, morphology, vitality & DNA Fragmentation Index with unmatched accuracy with inbuilt QC/ QA checks.
Useful information:
Percentile value represents a range where the upper and lower reference limits (obtained by high quality reference data - WHO 5th manual and Asian Journal of Andrology 2010) define threshold levels of minimum and optimal numbers. Statistically, if the threshold levels are below 5th percentile pregnancy possibilities are extremely low and similarly if the levels are above 75th percentile pregnancy possibilities reach near normal population levels. The reporting format (first in India) ensures planning of cost effective solutions for male fertility problems.
Note: CASA - Semen Analysis is a guide to fertility and facilitates planning management. The report needs to be interpreted by the treating physician with corresponding clinical factors and is not a proof of fertility.
CASA sperm motility CASA sperm morphology
ADVANCED ANDROLOGY LABORATORY
5th and 75th percentile reference values
Volume 1.7 ml – 2.0 ml
Ph 7.2
Liquefaction 30 min
Vitality > 58 % of cells
Agglutination – MAR test
Fructose Positive
White Blood cells
Peroxidase-positive leukocytes
Seminal neutral glucosidase Greater than or equal to 20 (mU/ejaculate)
Test
5th Percentile value
(Minimum numbers - WHO 5th manual) 75th Percentile value
(Optimum numbers)
Sperm Concentration Total Ejaculate > 40 mill for total ejaculate > 120 Million
Sperm Concentration / ml > 16 mil / ml > 40 Million
Motility Progressive > 33 % > 40 %
Total Motility (Progressive + Non Progressive) > 42 % > 50 %
Advanced Total Motility
Rapid Progressive 10 % 15 %
Slow Progressive 23 % 25 %
Morphology > 4% Normal forms > 9 %
Acrosome Intactness Index > 50 %
Excessive residual cytoplasm (ERC)
Testicular sperm producing capacity
per day per ml of testicular volume 0.25 million 1.25 million
VSL 17-67 micro mt/sec
VCL 25-100micromt/sec
H max assay 6.8 + 1.7
QC / QA: Quality assurance (QA) and Quality control (QC) as per WHO 5th manual are strictly followed as Semen Analysis is a multivariate sample. Volume by weight/ computer assisted motility & morphology-CASMA & Peroxides stain for WBC with Tygerberg-Kruger morphology
Recent Andrological advances: Advanced Andrology tests: Our advanced Andrology laboratory performs the following unique tests for the first time in India, to aid in specific management of Male Fertility problems:
1. DNA fragmentation index assessment for internal sperm defects - DFI
2. Sperm Functional Integrity assessment - SFI
3. Reactive Oxygen Species estimation - ROS
The following tests will be introduced shortly:
1. Sperm Developmental Defect assessment – SDD
2. Biological Fertility Assessment (Men) - Spermatogenesis, Spermiogenesis & Functional fertility assessment - BFA
(BFA is a comprehensive test which can predict fertility and identify the site of problems in men) – Contact your doctor or our lab for specific information.
Copyright©2010 Ankur
Dr. Vasan S S Mr. Ganesan K K
Director - UroAndrologist Lab Manager
Andrology team: Chaitra suma , Ashwini, Gomathi, Chitra
ADVANCED ANDROLOGY LABORATORY
SPERM FUNCTIONAL INTEGRITY ASSESMENT - SFI
Flagellar Integrity - Hypo Osmotic Swelling 41%
Osmotic Swelling Test
Normal : > 55 % spermatozoa with tail coiling
Significance : This test is a good index of healthy spermatozoa.
Clinical Relevance : Decrease in HOS positive reaction indicates loss of viability hence may be an indication of degenerative changes occurring
Spermiation defects - Acrosome Reaction after Ionophore Challenge 04%
ARIC Test
Normal : > 15 % spermatozoa with halos having mean diameter of 10 m
Subnormal : > 10-15 % spermatozoa with halos having mean diameter of 10 m
Abnormal :
Significance : This test evaluates the functional status of sperm acrosome and is
a good indicator of sperm’s ability to penetrate the oocyte.
Clinical Relevance : Decrease in Acrosome positive reaction indicate the
Possibility of low or nil fertilization.
Seminal Vesicle marker - Zinc concentration NA
Zinc concentration Test
Normal : 2.4 μmoL per ejaculate
Significance : The function of the accessory gland is assessed by the content of Zinc and
Zinc has been found to be critical to spermatogenesis
Clinical Relevance : Lower concentrations imply abnormal function of the accessory gland
High zinc concentrations have been reported to depress oxygen uptake in the sperm celL.
PLEASE GO THROUGH THIS REPORT AND HELP ME IN THIS REGARD...
ADVANCED ANDROLOGY LABORATORY
COMPUTER ASSISTED SPERM ASSESSMENT (CASA)
Name MR. SURESH KUMAR.S Age 34 Yrs Hosp No
Abstinence days 03 Volume → 2.6 ml
Time of Collection 09.40 AM Time of Evaluation 10.10 AM Spillage: No
Fructose → Positive Pus cells→ 01/hpf Not Significant Ph → 8.0 Liquefaction → Normal Live → 39 % Dead → 61 %
CONCENTRATION ASSESSMENT (5th percentile value)
Total Ejaculate
Millions 218 million
Total Ejaculate: Normal
(5th per: 40 75th per: 120)
Sperm Conc.
(millions / ml 84 mill/ml
MOTILITY ASSESSMENT (5th percentile value)
Sperm Motility 1 Hr 2 Hrs
Total Progressive 27% 12%
Non Progressive 08% 10%
Immotile 65% 78%
Total motility
(Total Progressive + Non Progressive) 35% 22 %
1 Hour Total motility: Sub Normal
(5th Per: 42 75th Per: 50)
Advanced CASA parameters Micro mt/sec
Straight Line Velocity-VSL 00.0
Curvilinear Velocity –VCL 28.0
Hyper activation –H max assay 00.0
Advanced Total Progressive Motility Assessment (CASMA)
Rapid Progressive 00%
Slow Progressive 27%
Advanced Total progressive motility: Sub Normal
(5th Per: 10 75th Per: 15)
MORPHOLOGY ASSESSMENT (TYGERBERG KRUGER) (5th percentile value)
Morphology %
Normal Forms 02%
Over all Defects 98%
Sperm Morphology: Sub Normal
(5th Per: 4 75th Per: 9)
Head Defects 67%
Mid Piece and Neck Defects 20%
Tail Defects 11%
Multiple Defects 33%
Excessive residual cytoplasm (ERC) 03%
Ex. residual cytoplasm: Not Significant
ADVANCED ANDROLOGY LABORATORY
ADDITIONAL PARAMETER ASSESSMENT
Round cells: Nil Bacteria: Not significant
RBC: Nil Agglutination: Nil Cellular debris: Not significant
Special Comment :
Final Impression- ASTHENOTERATOZOOSPERMIA
1. Terminology used in final impression is on the basis of total ejaculate concentration, motility & morphology. Additional parameter reported needs to be evaluated independently by the physician.
2. Impression based on 5th percentile value, however, 75th percentile value may be optimum and treatment plan may be suitably
decided by the physician.
3. 75th percentile value was decided optimum instead of 90th percentile by our clinical database and international opinion - to avoid too large an indeterminate group.
CASA: Computerised semen analysis is done with sperm class analyzer (http://www.spermclassanalyzer.com/) which provides fast, accurate & objectively repeatable results. This sophisticated software reports concentration, motility, morphology, vitality & DNA Fragmentation Index with unmatched accuracy with inbuilt QC/ QA checks.
Useful information:
Percentile value represents a range where the upper and lower reference limits (obtained by high quality reference data - WHO 5th manual and Asian Journal of Andrology 2010) define threshold levels of minimum and optimal numbers. Statistically, if the threshold levels are below 5th percentile pregnancy possibilities are extremely low and similarly if the levels are above 75th percentile pregnancy possibilities reach near normal population levels. The reporting format (first in India) ensures planning of cost effective solutions for male fertility problems.
Note: CASA - Semen Analysis is a guide to fertility and facilitates planning management. The report needs to be interpreted by the treating physician with corresponding clinical factors and is not a proof of fertility.
CASA sperm motility CASA sperm morphology
ADVANCED ANDROLOGY LABORATORY
5th and 75th percentile reference values
Volume 1.7 ml – 2.0 ml
Ph 7.2
Liquefaction 30 min
Vitality > 58 % of cells
Agglutination – MAR test
Fructose Positive
White Blood cells
Peroxidase-positive leukocytes
Seminal neutral glucosidase Greater than or equal to 20 (mU/ejaculate)
Test
5th Percentile value
(Minimum numbers - WHO 5th manual) 75th Percentile value
(Optimum numbers)
Sperm Concentration Total Ejaculate > 40 mill for total ejaculate > 120 Million
Sperm Concentration / ml > 16 mil / ml > 40 Million
Motility Progressive > 33 % > 40 %
Total Motility (Progressive + Non Progressive) > 42 % > 50 %
Advanced Total Motility
Rapid Progressive 10 % 15 %
Slow Progressive 23 % 25 %
Morphology > 4% Normal forms > 9 %
Acrosome Intactness Index > 50 %
Excessive residual cytoplasm (ERC)
Testicular sperm producing capacity
per day per ml of testicular volume 0.25 million 1.25 million
VSL 17-67 micro mt/sec
VCL 25-100micromt/sec
H max assay 6.8 + 1.7
QC / QA: Quality assurance (QA) and Quality control (QC) as per WHO 5th manual are strictly followed as Semen Analysis is a multivariate sample. Volume by weight/ computer assisted motility & morphology-CASMA & Peroxides stain for WBC with Tygerberg-Kruger morphology
Recent Andrological advances: Advanced Andrology tests: Our advanced Andrology laboratory performs the following unique tests for the first time in India, to aid in specific management of Male Fertility problems:
1. DNA fragmentation index assessment for internal sperm defects - DFI
2. Sperm Functional Integrity assessment - SFI
3. Reactive Oxygen Species estimation - ROS
The following tests will be introduced shortly:
1. Sperm Developmental Defect assessment – SDD
2. Biological Fertility Assessment (Men) - Spermatogenesis, Spermiogenesis & Functional fertility assessment - BFA
(BFA is a comprehensive test which can predict fertility and identify the site of problems in men) – Contact your doctor or our lab for specific information.
Copyright©2010 Ankur
Dr. Vasan S S Mr. Ganesan K K
Director - UroAndrologist Lab Manager
Andrology team: Chaitra suma , Ashwini, Gomathi, Chitra
ADVANCED ANDROLOGY LABORATORY
SPERM FUNCTIONAL INTEGRITY ASSESMENT - SFI
Flagellar Integrity - Hypo Osmotic Swelling 41%
Osmotic Swelling Test
Normal : > 55 % spermatozoa with tail coiling
Significance : This test is a good index of healthy spermatozoa.
Clinical Relevance : Decrease in HOS positive reaction indicates loss of viability hence may be an indication of degenerative changes occurring
Spermiation defects - Acrosome Reaction after Ionophore Challenge 04%
ARIC Test
Normal : > 15 % spermatozoa with halos having mean diameter of 10 m
Subnormal : > 10-15 % spermatozoa with halos having mean diameter of 10 m
Abnormal :
Significance : This test evaluates the functional status of sperm acrosome and is
a good indicator of sperm’s ability to penetrate the oocyte.
Clinical Relevance : Decrease in Acrosome positive reaction indicate the
Possibility of low or nil fertilization.
Seminal Vesicle marker - Zinc concentration NA
Zinc concentration Test
Normal : 2.4 μmoL per ejaculate
Significance : The function of the accessory gland is assessed by the content of Zinc and
Zinc has been found to be critical to spermatogenesis
Clinical Relevance : Lower concentrations imply abnormal function of the accessory gland
High zinc concentrations have been reported to depress oxygen uptake in the sperm celL.
Wed, 21 Aug 2013
Hello and welcome to HCM,
The semen analysis report is as follows:
1. The volume of ejaculate is within normal limits. In health, the volume should be atleast 2 ml/ ejaculate.
2. The sperm conc/ml of semen is within normal limits. In health, sperm concentration should be atleast 20 million/ml. In your case sperm conc is more than 20 million/ml.
3. Motility: At least 50 % perms should show progressive forward motion. In your case the motility is less than 50 %.
4. Morphology: In health, atleast 50 % sperms should have normal morphology. In your case, there are many structural defects and dead sperms and thus morphology is sub-normal.
5. Rest of the physical characteristics i.e. volume, pH, liquefaction of semen, viscosity are within normal limits.
6. There is no evidence of infection in the semen.
A repeat semen analysis should be done since, asthenoteratozoospermia suggests inability to bear children.
Thanks and take care
Dr Shailja P Wahal
The semen analysis report is as follows:
1. The volume of ejaculate is within normal limits. In health, the volume should be atleast 2 ml/ ejaculate.
2. The sperm conc/ml of semen is within normal limits. In health, sperm concentration should be atleast 20 million/ml. In your case sperm conc is more than 20 million/ml.
3. Motility: At least 50 % perms should show progressive forward motion. In your case the motility is less than 50 %.
4. Morphology: In health, atleast 50 % sperms should have normal morphology. In your case, there are many structural defects and dead sperms and thus morphology is sub-normal.
5. Rest of the physical characteristics i.e. volume, pH, liquefaction of semen, viscosity are within normal limits.
6. There is no evidence of infection in the semen.
A repeat semen analysis should be done since, asthenoteratozoospermia suggests inability to bear children.
Thanks and take care
Dr Shailja P Wahal
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