My Husband Takes Metformin,propranolol , Nexium, Benicar Hct He Is

My husband takes metformin,propranolol , nexium, benicar hct he is 66 yrs old he's lost about 30lbs in about a year his skin is starting to really sag under his arms his legs got real skinny he has no appetite very dry mouth all he does is sit on sofa all day and play on his iPad. He was always very very active . It's got to bother him being so tired all the time he's thinking about just stop taking all of his meds what do u thin?