My Sister, 60 Years Old, Has Not Been Feeling Well,

My sister, 60 years old, has not been feeling well, her eyes do not sparkle anymore. For a month or more she looks like she is not healthy. I asked her if she was feeling ok. She responded that she is having the following symptoms: tingling in her feet, leg, back and rib cage cramping, fatigue even after sleeping all night. Her voice is now
getting hoarse. She has made an appointment with her general practioner for wed. Any idea about what these symptoms might be related to?